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CRT and Bayer Schering Pharma to Investigate New Therapeutic Approach in Gynaecological and Oncological Diseases

Published 25 August 2010 | By Cancer Research Technology (CRT)

Cancer Research Technology Ltd. (CRT) has signed an agreement with Bayer Schering Pharma AG, Germany, to evaluate new leptin antagonist peptides as potential experimental treatments initially in the area of gynaecological diseases, including cancer.

Under the terms of the agreement, Bayer Schering Pharma will evaluate the ability of the peptides to switch off the activity of a protein called leptin in a first evaluation phase. After the evaluation period both parties have the option to enter into a license agreement for the technology, the major terms of which have been agreed.

Leptin triggers the growth of different types of cells including endometrial cells and has been linked to angiogenesis – new blood vessel growth. It is hoped that blocking leptin's action will offer a potential new treatment for a range of cancers and gynaecological diseases.

The leptin antagonists were first developed at the Boston Biomedical Research Institute (BBRI) in the US by Dr Paul Leavis and Dr Ruben Gonzalez who have shown that the peptides are effective in blocking the effects of leptin in several diseases.

CRT, through its US subsidiary, CRT Inc, had agreed with BBRI to market and commercialise the technology and also provided support to BBRI for further development of the inhibitors and this agreement represents the successful outcome of these activities.

Larry Steranka, managing director of CRT Inc, said: "We're delighted to have worked alongside BBRI to partner its technology with the right commercial partner to take forward the development of potential new treatments. We're looking forward to using our expertise and access to the international community to connect other US institutions with industrial partners and assist in the commercialisation of their technologies."

Charles Emerson Jr, director of the BBRI, said: "CRT is an excellent partner to work with and has made a real impact in helping commercialise this project. We look forward to seeing the project progress with our industrial partner and to working with CRT again in the future".