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CTL Laboratories


CTL Laboratories

Cellular Technology Limited (CTL), headquartered in Shaker Heights, OH, is a privately held biotechnology company that built its reputation as the global leader in the ELISPOT field over the past two decades by establishing the ELISPOT instrumentation and scientific principles that have helped to define the parameters of ELISPOT research for monitoring of Cell-Mediated Immunity.

CTL Laboratories provides contract laboratory services to pharmaceutical and biotechnology companies, government agencies, and academic institutions. CTL specializes in Cell Mediated Immune Monitoring services for research, preclinical studies, and clinical trials.

With a focus on high-throughput ELISPOT assays, multiplex Cytokine Bead Arrays (CBA), Flow Cytometry (phenotyping, multimer readouts etc.), and BrdU proliferation assays, CTL is uniquely capable of developing, qualifying and validating assays tailored to our clients’ specific needs in our GLP-compliant and CLIA-certified laboratory.


Contact details:
Cellular Technology Limited

20521 Chagrin Boulevard
Shaker Heights
OH 44122-5350
Phone: +1 216-791-5084
Fax: +1 216-791-8814

Analysis of Morphometric Bioassays with CTL’s BioSpot® Image Analysis Platform

Objective, scientifically validated counting algorithms ensure accurate results for yeast viability analysis, NK assays, viral plaque assays, clonogenic and genotoxicity assays, and bacterial colony counting.

In recent years Cellular Technology Limited (CTL) has further customized and optimized our instruments, introducing the BioSpot® Analysis Platform for various applications in the biotechnology and pharmaceutical industries, e.g., Yeast Viability Assessment, Viral Plaque Assays, Clonogenic and Genotoxicity Assays, and Bacterial Colony Counting. This has allowed us to enter into new markets while advancing the…

Assay Standardisation for Monitoring of Cell Mediated Immunity

Access up to 2,000 vials of cryopreserved PBMC from a single donor from our extensive library of established antigen reactivity and HR HLA-typed healthy donors (over 100) to enable standardisation of your cell-based assays.

Supporting cell-based assay standardisationCTL is the premier provider of comprehensive standardisation packages for cellular assays. These include:Serum-free media solutions and cryopreservation reagentsStandardised antigens (CEF peptide pools)Cryopreserved PBMC - characterised for HLA types and established antigen reactivityELISPOT reference sample QC set - characterised cryopreserved PBMC with high, low, and no production of a particular cytokine in…

ELISA, Multiplex, and Flow Cytometry Testing

CTL’s ELISPOT assay expertise is complemented by its ELISA testing, multiplex bead array (CBA), and flow cytometry services (FACS).

ELISA testing can be used to extract additional information on the production of antibodies or other cytokines from the same sample -- that is, without requiring the use of additional blood draws. Similarly, flow cytometry can be used to determine which cell population is prevalent in the monitored response. It is also an invaluable tool…

ELISPOT ImmunoSpot® Analysers

ELISPOT assays are the ideal readout system for cytokine-based immune monitoring and standardsation strategies.

In addition to our CLIA certified, GLP-compliant laboratory operations in which we perform ELISPOT (Enzyme-Linked ImmunoSpot® Assay) assays for our clients (includes development, validation and high throughput testing for preclinical and clinical studies), Cellular Technology Limited (CTL) specializes in developing and manufacturing image-based analysis, high-throughput 21 CFR Part 11 compliant instrumentation and software.To facilitate the…

High-Throughput Immune Contract Laboratory Services

A four to five week turnaround time for up to 1,000 subjects assayed for antigen-specific cytokine responses allows you to significantly accelerate immune monitoring of patient samples.

Cellular Technology Limited (CTL) has many years of experience in performing contracted laboratory services. Our laboratory complies with CLIA and FDA regulations (21 CFR Part 58 and 21 CFR Part 11). CTL's greatest strength lies in its high-throughput T cell monitoring capabilities and world-class ELISPOT (Enzyme-Linked ImmunoSpot® Assay) expertise. We can offer a four- to…

Monitoring of Cell Mediated Immunity Focusing on T and B Cells

ELISPOT assays are the Ideal readout system for cytokine-based immune monitoring and standardisation strategies.

ELISPOT assays, and the related multiplex FluoroSpot technology, are ideal for measurement of per-cell antigen-specific cytokine production and direct ex vivo cytotoxicity assays. T cell functional avidity studies and epitope mapping, and B cell ELISPOT assays for determining the class or subclass of antibody-secreting cells, are just a few areas where ELISPOT and FluoroSpot are…

Specimen Management

CTL’s specimen management department is solely dedicated to monitoring pre-clinical and clinical samples from receipt to disposition.

Our thorough quality control measures ensure proper specimen handling and accurate data management. The movement of every specimen is tracked meticulously until CTL receives disposition instructions from the sponsor/client.CTL is a member of the International Society for Biological and Environmental Repositories (ISBER), the leading international forum that addresses the technical, legal, ethical, and managerial issues…

Specimen Processing

CTL provides laboratory services for processing and cryopreserving both pre-clinical and clinical specimens.

 Our scientific team has a wealth of experience in processing whole blood to obtain peripheral blood mononuclear cells, (PBMC) or separate cell populations (CD4, CD8, NK cells, monocytes, and others). We also have experience in the processing of solid organs (e.g., spleens, lymph nodes) to obtain lymphocytes.From any given blood sample, we can isolate the…

Contracted ELISPOT Testing for Immune Monitoring and Biomarker Screening in Pre-clinical Studies and Clinical Trials

CTL has years of experience in contracted research. Many pharmaceutical and biotechnology companies have entrusted CTL with evaluating cell-mediated immunity (CMI) to their vaccines, drugs, and biologic products using the ELISPOT technique.

Are you using the appropriate readout system for evaluating your test subject response?CTL's greatest strength lies in its high-throughput T cell monitoring capabilities and world-class ELISPOT (Enzyme-Linked ImmunoSpot Assay) expertise.The ELISPOT technique allows researchers to generate secretory footprints in the form of colored spots within a 96-well plate. These images are then scanned, counted, and…
Quick Contact CTL Laboratories
Quick Contact CTL Laboratories

 Alliance Selects SCM for Sterile Product Supply

SPECIALITY pharmaceutical company Alliance Pharma has awarded a commercial supply contract for three of its products to sterile manufacturing expert...
26th August 2011
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Quick Contact CTL Laboratories

TVA™ – Non-Radioactive NK/ADCC Assessment

Traditionally, Natural Killer (NK) cell-mediated lysis of K562 tumor cells has required laborious, time consuming, radioactive Chromium Release Assays (CRA)....
9th February 2016
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Quick Contact CTL Laboratories

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