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Detection of Antigen-Specific T-Cell Lineages and Effector Functions

T-cells not only protect us from infectious diseases and cancer, but are involved in transplant rejection, autoimmune diseases and allergies.

Each of these immunologic processes share a common link in what antigen-specific T-cells undergo expansion, with some of the resulting progeny differentiating into memory cells.

Memory T-cells belong to several distinct lineages and sublineages that fundamentally differ in their effector functions and capacity to mediate a protective or pathological immune response. In this mini-review, CTL outlines how such memory T-cell subpopulations can readily be identified on the basis of their secretory signature using a multi-colour ImmunoSpot® assay.

This article was originally published in the Journal of Immunological Sciences 2019.