HealthCore Publishes Comparative Study Of Oral Controllers With Inhaled Products
Effectiveness research study showed that asthma patients had better overall results with oral controllers
A comparative effectiveness study performed by HealthCore published by Mayo Clinic has showed that asthma patients in general had better clinical outcomes with oral controllers than inhaled corticosteroids.
The study, Impact of Asthma Controller Medications on Clinical, Economic and Patient-Reported Outcomes, revealed that users of oral controllers were significantly better at adhering to their medication than users of inhaled corticosteroids and probably obtained greater treatment benefit.
Reportedly, the comparative effectiveness research study assessed the use of short-acting beta-agonists, use of oral corticosteroids, inpatient/emergency room visits, and total cost of care attributable to asthma during the 12-month period after the index date.
Both oral and inhaled treatments offered comparable impacts. Among patients taking more than one drug to control their asthma, HealthCore found that a combination of inhaled corticosteroids and long-acting beta-agonists were the best course of treatment in terms of better clinical outcomes and better quality of life.
In the group of patients who adhered to their medication, those taking leukotriene modifiers-oral asthma controllers-were more likely to have an emergency room or inpatient physician visit, less likely to use six or more short-acting beta agonist canisters and incurred higher annual costs.
Moreover, those who were compliant with their inhaled corticosteroids had better outcomes than those who adhered to their oral controllers, but so few of those taking inhaled corticosteroids adhered properly to their medication, that it had little impact on the overall population studied.
Joseph Singer, vice president of clinical affairs for HealthCore, said: WellPoint's National Pharmacy and Therapeutics Committee requested the comparative effectiveness study to help ensure that its drug formulary for asthma therapies was aligned with their real-world use and outcomes.
However, we were surprised to discover that in looking at all patients in real-world settings, oral controllers appeared to be a better choice of treatment because of better compliance. Patients with the best outcomes were those who were compliant with inhaled corticosteroids.
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