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Mercachem provides a wide range of chemical services to the life sciences industry. We specialise in exclusive synthetic and process chemistry services to support research and development programs of companies across the globe.

Organic reactions ranging from milligram to1 kilogram

We have the equipment and knowledge necessary to carry out organic reactions ranging from milligram to 1 kilogram scale. Moreover, we offer parallel synthesis of focused libraries. Mercachem’s process research services focus on the development of efficient production processes for selected candidates.


Mercachem is an independent, privately held, contract research company located in Nijmegen, the Netherlands. Founded in 1997, Mercachem employs nearly 110 people, almost 50% of whom hold post-graduate degrees in Chemistry. Mercachem delivers fully integrated exclusive (medical) organic, synthetic and process chemistry services to support research and development programs to companies across the globe.

Our primary market is the Life Sciences industry in Western Europe and the U.S. Mercachem is a dynamic organization with high standards of quality and efficiency, creative people, outstanding communication and modern facilities and equipment.

Vision and ambition

The Life Sciences industry is under ever-increasing pressure to introduce new and more effective products to market. In the last decade, readily-accessible libraries, which can be screened rapidly for activity in various therapeutic areas, have become available from diverse sources.


There is a wide gap, however, between the initial lead identification and candidate development, which results in a need for synthetic chemical capabilities. Mercachem has taken a leading role in closing that gap.

State-of-the-art custom synthesis and research services

Outsourcing of synthesis projects to support this process has matured and has become an integral component of the R&D strategy in the Life Sciences industry.

Mercachem offers state-of-the-art custom synthesis and research services to accelerate the R&D process efficiently and cost-effectively



Kerkenbos 1013
6546 BB Nijmegen
The Netherlands

Phone: +31 (0)24-3723300
Fax: +31 (0)24-3723305




Discovery Chemistry Services

Mercachem offers different business models and services:Custom Synthesis and Contract ResearchAt MercaChem we are able to synthesize a large variety of molecules including:Building blocks, scaffolds and synthons for parallel chemistry or further synthesisNew chemical entities or analogues for lead discovery and optimizationReference compounds such as metabolites or impurities for process validationMercachem offers lab-scale (100 mg…

Medicinal Chemistry Services

Mercachem can work on the following type of projects:Design and synthesis of druglike compoundsHit optimizationHit-to-LeadLead optimizationExperimental measurement of physical and chemical propertiesThe basis of this service from Mercachem is two-fold: the vast experience in pre-clinical research in pharmaceutical industry of our staff, and the broad knowledge in synthetic organic chemistry.Using a wide variety of optimization…

Process Research

Mercachem's process research services are aimed at the development of efficient production processes of your target molecules.The process research services include:Route scoutingReaction and process optimizationCatalyst screeningMaterial supply (~1 kg, non-GMP)We use modern research techniques such as parallel experimentation and statistical methods such as Design of Experiment and multivariate data analysis to systematically and effectively optimize…
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