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Life Chemicals Inc.

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Life Chemicals Inc.

Life Chemicals Inc, established in 2004, specialises in development, production and sales of novel screening compounds for HTS, targeted screening libraries and core building blocks for drug discovery projects.

Relying on powerful material and technical basis, long term experience and excellent knowledge of modern medicinal and synthetic organic chemistry Life Chemicals offers advanced custom synthesis and computational chemistry services to pharmaceutical, animal health and crop protection industries as well as to research institutions across the globe.

So far we completed over 2000 custom synthesis and hit-to-lead optimisation projects for over 1500 customers in 46 countries of the world. Being a fully integrated company Life Chemicals employs over 100 highly qualified professionals including 23 PhDs in organic, medicinal and pharmaceutical chemistry.

The high quality standards of our products and services are ensured by the use of high-end equipment and modern facilities specialised for organic synthesis, combinatorial chemistry, quality control and storages. In-house elaborated production processes and advanced logistic system enable the safe and on-time delivery of Life Chemicals compounds.

Propriety Collection of Small Organic Molecules for HTS

Life Chemicals’ collection of small organic molecules for high-throughput screening currently contains more than 860,000 compounds including 385,000 off-the-shelf compounds synthesized in-house and 475,000 tangible database of diverse compounds built around 2,600 original scaffolds.

All the compounds are novel, drug-like, lead-like, diverse and well-characterised molecules representing wide chemical space. The purity of the compounds is at least 90%, the quality is backed with NMR and/or LCMS assays data. Our HTS compounds collection is being permanently replenished with de-novo designed compounds with optimal physicochemical parameters for drug discovery purposes. To…

Computational Chemistry Services

Life Chemicals offers broad spectrum of computational chemistry services based on miscellaneous in silico methods supported by advanced specialised software:

Sybyl-X 2.1 Schrodinger Maestro/Glide/LigPrep/Macromodel Gromacs Gamess-UK Python scripting for calculation of descriptors Visualizers (DS, Marvin View/Sketch)Standard ServicesCustom filtering (toxic, reactive, specified groups, PAINS)Similarity search (Tanimoto/Cosine coefficient)Dissimilarity searchSubstructure searchMolecular descriptors calculationProtein modelingHomology modelingGeometry optimizationStructure assessmentMolecular dynamicScreening/docking methodsFlexible docking: Surflex-dock, Surflex-sim, GlideIn silico screening search: UNITY model, GALAHAD, 3DQSAR

Building Blocks

Life Chemicals offers more than 13,000 building blocks for in-house synthesis projects including 6,000 in stock collection and 7,000 tangible compounds available through in-house synthesis within 2-4 weeks. Each building block in the Stock collection is 95%+ pure, NMR and LCMS analytical information is provided free-of-charge upon request. Express delivery within 2 working days is possible from stocks in the US, Germany and Japan.

Custom Synthesis Service

Life Chemicals provides expertise in organic chemistry and developed platform for custom synthesis projects. The success rate for custom synthesis is over 85%. The services are offered on the basis of both fixed price and FTE approaches. Scale-up synthesis in amounts up to 100kg is possible.

Synthesis of individual compounds:Building blocksReference compounds and potential impuritiesMetabolitesNew chemical entities and analogs for hit-to-lead developmentPeptidomimeticsDrug-like compoundsSynthesis of compound libraries:Libraries based on scaffolds of Life ChemicalsLibraries based on scaffolds of the customerCustom targeted librariesDiversity librariesProcess optimisation:Route scouting and scale-upReaction and process optimisationCatalyst screeningCharacterisation of physical and chemical propertiesEarly drug discovery (improvement of potency, selectivity and…

Fragment Libraries

Fragment based drug discovery has been shown to be highly effective and promising alternative to high-throughput screening. Life Chemicals offers original Fragment Library containing 50,000 lead-like, small MW (

In accordance with the most efficient tendencies in fragment based approach to drug discovery Life Chemicals has prepared following unique subsets:General Fragments LibrarySuperior Fragment LibraryFragment Library with Guaranteed SolubilityFsp3-enriched Fragment LibraryFluorinated Fragment LibraryBromine-based Fragment LibraryPPI Fragment Library3D Fragment Library"Start Small & Stay Small" Zenobia Therapeutics and Life Chemicals joint fragment library

Targeted Libraries

Targeted Libraries are pre-selected subsets of Life Chemicals stock available compounds with potential activity towards certain biological targets. To design the Targeted Libraries both receptor-based and ligand-based approaches were used along with various advanced chemoinformatic techniques such as similarity and substructure searches and virtual docking.

Life Chemicals offers following Targeted Libraries:Enzymes Targeted Libraries: Kinases, Proteases, Polymerase, ATPase, Phosphatase, CYP inhibitorsSharp Focused Kinases Libraries: FGFR1K, PDK-1, PKA, PI3K, JAK, ROCK, ERK5Transporters Targeted Libraries: Ion Channels, AquaporinsGPCRs Targeted libraryProtein-protein Interactions InhibitorsEpigenetics Targeted LibrariesNuclear Receptors Targeted LibraryActivity Targeted Libraries: Antibacterial, Antiprotozoa, Antituberculosis, Antiviral, Anticancer, CNSAgro-like Library: Insecticides, Fungicides, Herbicides, MicrobiocidesNatural Product-like Compounds LibraryCovalent…
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