Custom Synthesis Service

Life Chemicals provides expertise in organic chemistry and developed platform for custom synthesis projects. The success rate for custom synthesis is over 85%. The services are offered on the basis of both fixed price and FTE approaches. Scale-up synthesis in amounts up to 100kg is possible.

Synthesis of individual compounds:

• Building blocks
• Reference compounds and potential impurities
• Metabolites
• New chemical entities and analogs for hit-to-lead development
• Peptidomimetics
• Drug-like compounds

Synthesis of compound libraries:

• Libraries based on scaffolds of Life Chemicals
• Libraries based on scaffolds of the customer
• Custom targeted libraries
• Diversity libraries

Process optimisation:

• Route scouting and scale-up
• Reaction and process optimisation
• Catalyst screening
• Characterisation of physical and chemical properties

Early drug discovery (improvement of potency, selectivity and ADMET):

• Hit optimisation
• Hit to lead
• Lead optimisation

Our researchers work in various fields of modern organic chemistry, concentrating, in particular, on heterocyclic and element organic chemistry. Up-to-date equipment and professional skills of our chemists afford advanced chemistry practice:

• Handling of gaseous reagents including selective catalytic hydrogenation
• Fluorination with CF3CHN2, SF4/HF, SbF3, DAST, Morph-DAST, Deoxo-Fluor, CF3I, Halothane, Freon-113
• Microwave-assisted synthesis
• Asymmetric synthesis involving chiral auxiliary groups, chiral homogeneous catalysts, separation of racemates
• Multigram scale photochemistry
• Handling of flammable reducing agents: LAH, DIBAL, AlH3, Vitride, L-Selectride, Super-Hydride, BH3, LiHMDS, n-BuLi, sec-BuLi, t-BuLi, MeLi, LDA, LTMP
• Use of toxic metalorganic reagents (Mg, Zn, Cd, Hg, Sn, Bi)
• Chemistry in liquid ammonia