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More info about Life Chemicals Inc.

Custom Synthesis Service

Life Chemicals Inc.

Life Chemicals provides expertise in organic chemistry and developed platform for custom synthesis projects. The success rate for custom synthesis is over 85%. The services are offered on the basis of both fixed price and FTE approaches. Scale-up synthesis in amounts up to 100kg is possible.

Synthesis of individual compounds:

  • Building blocks
  • Reference compounds and potential impurities
  • Metabolites
  • New chemical entities and analogs for hit-to-lead development
  • Peptidomimetics
  • Drug-like compounds

Synthesis of compound libraries:

  • Libraries based on scaffolds of Life Chemicals
  • Libraries based on scaffolds of the customer
  • Custom targeted libraries
  • Diversity libraries

Process optimisation:

  • Route scouting and scale-up
  • Reaction and process optimisation
  • Catalyst screening
  • Characterisation of physical and chemical properties

Early drug discovery (improvement of potency, selectivity and ADMET):

  • Hit optimisation
  • Hit to lead
  • Lead optimisation

Our researchers work in various fields of modern organic chemistry, concentrating, in particular, on heterocyclic and element organic chemistry. Up-to-date equipment and professional skills of our chemists afford advanced chemistry practice:

  • Handling of gaseous reagents including selective catalytic hydrogenation
  • Fluorination with CF3CHN2, SF4/HF, SbF3, DAST, Morph-DAST, Deoxo-Fluor, CF3I, Halothane, Freon-113
  • Microwave-assisted synthesis
  • Asymmetric synthesis involving chiral auxiliary groups, chiral homogeneous catalysts, separation of racemates
  • Multigram scale photochemistry
  • Handling of flammable reducing agents: LAH, DIBAL, AlH3, Vitride, L-Selectride, Super-Hydride, BH3, LiHMDS, n-BuLi, sec-BuLi, t-BuLi, MeLi, LDA, LTMP
  • Use of toxic metalorganic reagents (Mg, Zn, Cd, Hg, Sn, Bi)
  • Chemistry in liquid ammonia
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