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SBW

Drug Candidate Validation Services

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SBW

SBW is a consolidated contract research organisation that provides an extensive range of world-class services for drug discovery and development.

SBW is equipped with state-of-the-art instrumentation operated by experienced pharma professionals from multiple disciplines. All our services can be tailor-made to fit specific customer needs. Our experience includes working with over 150 pharma / biotech customers in more than 20 countries.

SBW and its divisions form an innovative and dynamic biotechnology company for drug discovery and development services and related areas. We offer world class services for pharma and biotech industry and academic partners in drug discovery and development.

Phase III clinical trials, drug research and R&D

We provide our customers with a seamless model of our wide expertise and comprehensive platforms, from target discovery to the Phase III clinical trials. Our cost-competitiveness comes from combining our local European and Indian offshore resources.

A significant part of our resources goes towards R&D for innovation and development of novel methods for drug research in collaboration with academic entities and other research organisations and companies.

SBW Corp. Ltd
Mikonkatu 8
FI-00100 Helsinki
Finland

Tel: +358 10 439 9440
Fax: +358 9 678 783
info@sbw.fi
www.sbw.fi

Biostatistics, Bioinformatics, and Data Management and Warehousing

Biostatistics Data management Data warehousing Bioinformatics Medical writing Medical coding Monitoring (through partners) Full clinical study (through partners) Common technical document Remote data entry Electronic data capture (through partners) Pharmacovigilance (through partners)

Discovery Biology

Biomarker discovery using 2-dgel, MALDI-TOF/TOF, and other MS and phage display techniques Biomarker quantitation and validation Physicochemical characterisation of proteins / peptides and post-translational modifications using MS, NMR and CD techniques Fragment-based drug discovery analytics Custom peptide synthesis Recombinant DNA services Cloning and gene expression in bacterial and mammalian systems Gene silencing using siRNA techniques…

Disease Models, In Vivo PK, and Safety Pharmacology and Toxicology

Disease models Cardiovascular and metabolic diseases, diabetes, oncology, dermatology, gastrointestinal diseases and CNS models (e.g. Alzheimer’s and Parkinson’s, stroke and epilepsy) In vivo PK Available species are rat, mouse, dog, rabbit and guinea pig Formulation for dosing (vehicle finding and vehicle stability) Safety pharmacology and toxicology Modified Irwin test in mice and rats Locomotor activity…

Drug Candidate Validation Services

We offer a full range of services for drug candidate validation: SBW provides a range of in silico, in vitro and in vivo services for drug discovery, including early target identification, hit to lead, lead optimisation and pre-clinical steps.

SBW also provides a range of services for clinical trials: biostatistics and data management, warehousing and analysis. We offer biological activity and scaffold hopping (US patent pending); quantitative physico-chemical and ADME property prediction; and systemic, organ-specific, and genetic toxicity and side-effect prediction (US patent pending). Other chemoinformatics services include the following. Structure-based drug discovery Target…

Medicinal Chemistry Services

Comprehesive medicinal chemistry solutions for lead optimisation Chemistry design and coordination Computational chemistry Custom chemical library synthesis Custom in vitro and in vivo efficacy assays ADME in vitro and in vivo analytics

Metabolism Studies, Drug Interaction Studies and Bioanalytical Services

Metabolism studies Metabolite profiling and identification: biotransformation and structural analysis in vitro and in vivo Metabolic stability, profiling and kinetics in vitro and in vivo Identification of rate-limiting CYP enzymes in vitro Various liver and other organ preparations available in eight species Drug interaction studies CYP inhibition: cocktail study in microsomes or in hepatocytes CYP…

Pharmacokinetic Calculations, Permeability Studies and Basic Property Characterisation

Pharmacokinetic calculations Pharmacokinetic parameters AUC, t1/2, Cl, V, Tmax and Cmax Bioavailability Permeability studies Caco-2, MDCK and PAMPA Organ-specific permeability (lung and skin) Transporter interaction assessment Basic property characterisation Solubility, lipophilicity and pKa Plasma stability Protein binding
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