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Pharmacokinetic Calculations, Permeability Studies and Basic Property Characterisation

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Pharmacokinetic calculations

  • Pharmacokinetic parameters AUC, t1/2, Cl, V, Tmax and Cmax
  • Bioavailability

Permeability studies

  • Caco-2, MDCK and PAMPA
  • Organ-specific permeability (lung and skin)
  • Transporter interaction assessment

Basic property characterisation

  • Solubility, lipophilicity and pKa
  • Plasma stability
  • Protein binding
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