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Fios Genomics



Fios Genomics

Fios Genomics provides an extensive range of genomic and bioinformatic data analysis services for Pharma, CROs and academic & clinical research for applications in drug discovery & development for both human and animal health.

Our data analysis services include:

  • Biomarker Analysis
  • Microarray Analysis
  • Next Generation Sequence Analysis
  • Data Mining and Integration
  • Proteomics & Metabolomics
  • Agricultural Genomics

Our biomarker and microarray analysis services provide expert analysis, mining and interpretation of data from a variety of high-throughput genomic technology platforms for applications ranging from biomarker discovery & characterisation, pathway analysis, predictive toxicology, pharmacogenomics (patient stratification) and SNP genotype/ DNA sequence data.

We have extensive knowledge and expertise in therapeutic areas such as inflammation, immunology, oncology and infectious diseases which can be applied to the discovery, characterisation and validation of genomic biomarkers.

Fios Genomics also offers access to pre-clinical and clinical GLP laboratory services through preferred wet lab partners

Benefits of Fios Genomics’ Services

  • Compliance with FDA : Data analysis workflows and output reports fulfil FDA criteria FDA for Pharmacogenomic (PGx) and Pharmacogenetic (PGt) data submissions
  • Expert knowledge: extensive expertise in study design, statistical modelling, network analysis, genome annotation, bioinformatics and pathway biology enables insightful interpretation
  • Speed: automated data analysis using high performance computing provides rapid turnaround from raw data generation to analysis: in hours/days not days/weeks
  • Scalability: analysis of very large complex datasets: 1000s of samples analysed simultaneously utilising high performance computing and network-based approaches
  • Flexibility: bespoke analyses ensure the most appropriate analytical methods are tailored to your specific needs
  • Biological interpretation: more insightful information and additional value is derived from data through linkage to in-house knowledge base in key therapeutic areas


Contact details

Fios Genomics Ltd
King’s Buildings

Tel: +44(0) 131 472 4800
Fax: +44(0) 131 662 4678

Microarray Analysis

Fios Genomics offers a wide range of bespoke data analysis solutions for a variety of microarray application areas. Our bespoke analyses can incorporate standard statistical techniques as well as more advanced approaches such as network and pathway based analysis, clustering techniques and data mining/integration methods to produce a comprehensive picture of the underlying biology.

Our microarray analysis services include:Gene Expression AnalysisGene expression analysis enables the identification of key differences in genes and biological pathways in response to drug treatment or disease. Fios Genomics can offer comprehensive analysis of gene expression profiling data from all the major commercial microarray platforms (Affymetrix, Illumina, Agilent, RocheNimblegen), as well custom microarray platforms and…

Next Generation Sequence Analysis (NGS)

Fios Genomics offers a comprehensive range of services for the analysis of data from the latest Next Generation Sequence (NGS) technologies. NGS enables an individual’s entire genome to be assessed for transcriptomes or the level of variation (polymorphism). Genome-wide association studies (GWAS), SNP detection and haplotype analysis using NGS approaches can facilitate the discovery and typing of novel SNPs implicated in disease or response to drugs. Our services incorporate expert knowledge with advanced computing to enable efficient processing and analysis of large and complex datasets.

We can process NGS data from all the major technology platforms (Illumina, SOLiD, 454) for a wide range of applications:RNA-seq: whole transcriptome sequencing for differential gene expression analysisExome analysis: for identification of known and novel SNPs and indelsGenome-wide association studies (GWAS): to facilitate discovery of SNPs implicated in diseaseChIP-seq: analysis of DNA-protein interactionsMethyl-seq: bisulfite sequencing…

Data mining and integration

We can integrate, extract and mine data from different sources. Integration of data from a variety of analytical approaches is considerably more powerful than each approach on its own.

Examples include:Further data mining: pathway overlay of clusters can identify important targets and biological signatures of functional relevancemRNA and miRNA: we can identify statistically significant changes in miRNA levels that might have an effect on expression of genes in pathwaysmRNA and SNPs/indels: we can identify where SNPs/indels correlate with the effects on expression of related…

Agricultural Genomics

Animal and plant genomics and genetics play a significant role in vaccine & therapeutics development, breeding and selection for meat quality, milk production and pest resistance. Exactly the same principles and methods for identifying SNPs and biomarkers in human data can be applied to livestock (sheep, pig, cow and poultry) and plant data. The benefits for the agricultural industry are enormous.

At Fios Genomics we offer a range of services specifically tailored to animal and plant genomic data from the custom design and annotation of new microarrays, exploration of gene expression profiles (microarray or next-generation sequence based), and/or linkage/association analysis of a trait within a population. We can use our experience and expertise to assist in…

Biomarker Analysis

Fios employs a variety of data analysis approaches for discovery, characterisation and validation of genomic and proteomic biomarkers.

By combining our expertise in bioinformatic analysis of gene expression, next-generation sequencing and epigenetic data with our extensive knowledge in therapeutic areas such as inflammation, immunology, oncology and infectious diseases we can help you at every stage of the drug development process from pre-clinical research to clinical development for applications for identification and validation of:Drug…

Proteomics and Metabolomics

ProteomicsFios Genomics offers a wide range of services for the analysis of data generated by state-of-the art proteomics technologies, such as Shotgun LC-MS/MS, SELDI-TOF MS and MALDI-TOF MS and protein arrays. Proteomics is the study of the full repertoire of proteins encoded by the genome in a given cell, tissue or organism. It is used…
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