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Diazirines for Photoaffinity Labelling

Diazirines for Photoaffinity Labeling Diazirine is the smallest heterocycle that is stable in the dark but forms reactive carbene upon irradiation with light. The formed carbenes smoothly insert into C-H, N-H, and O-H bonds.

Therefore, diazirines are often used as photoreactive crosslinking reagents due to their small size, a short period of irradiation, and stability toward nucleophiles. In this context, Enamine offers a library of diazirines for drug design.

We offer more than 100 diazirines from stock on a 5-10 g scale.

Design and full list you can find at MedChem Highlights section of Enamine’s website or in the white paper attachment.