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Characterisation of the CMV-Specific CD4 Cell Response

When most humans become infected with human cytomegalovirus (HCMV), the immune system controls the infection, but the virus typically persists and can reactivate in states of immunodeficiency.

While the HCMV-specific CD8 cell and antibody response has been accessible to investigation, studies of the CD4 cell subsets have been limited by the low frequency of the antigen-specific CD4 cells in the peripheral blood mononuclear cell (PBMC).

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