When most humans become infected with human cytomegalovirus (HCMV), the immune system controls the infection, but the virus typically persists and can reactivate in states of immunodeficiency.
While the HCMV-specific CD8 cell and antibody response has been accessible to investigation, studies of the CD4 cell subsets have been limited by the low frequency of the antigen-specific CD4 cells in the peripheral blood mononuclear cell (PBMC).
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