Contract Research & Services

Cyntellect Enters Into Research Collaboration With Boston University

PBR Staff Writer Published 07 December 2009

To develop new techniques for monitoring living cells

Cyntellect has entered into a research collaboration agreement with the Boston University School of Medicine. The agreement focuses on advancing research in the roles of mitochondrial oxidative damage in degenerative, aging and metabolic diseases, such as anemia and diabetes.

Reportedly, Boston University scientists is expected to use Cyntellect’s Leap Cell Processing Workstation to analyse, purify and process cells with precision and simplicity within microplates, right where they are grown in the lab.

Orian Shirihai, director of the cell imaging core at Boston University, said: “Cellular imaging is central to our research and much effort is dedicated to developing novel techniques for monitoring living cells. Cyntellect’s Leap workstation will give us a valuable tool to advance our studies by adding unique cell processing capabilities within the context of a cell imaging system.

“We will study two disease models in which oxidative damage to mitochondria play a key role in the development of pathology. In diabetes, nutrient-induced oxidative damage has been shown to be a major mediator of endocrine dysfunction and beta cell loss. In bone marrow, oxidative damage can lead to the development of anemia and myelodysplastic syndrome.”

Fred Koller, president and CEO of Cyntellect, said: “We are very proud to undertake this program with Boston University. Mitochondria in ß-cells play a key role as integrators of nutrient signals and insulin secretion. The mechanisms that underlie deterioration of mitochondrial function during the development of diabetes are critical for understanding the etiology of this disease. The Leap workstation offers an ideal platform for dissecting the roles of mitochondria in ß-cells.”