The newly introduced term protodynamic can be defined as a proton-derived force that produces a change
in a living cell. The basic idea is to transport hydrogen ions (H+ or protons) from the mildly acidic extracellular medium into the cell, which causes intracellular acidification. The protodynamic mode of action and the efficacy of cis-UCA in various models of inflammation and cancer will be briefly presented in this paper.