REAL Database (RDB) is a tangible array of 16 million diverse drug-like structures. The compounds are synthesized in single step using excessively validated chemical procedures from available building blocks.
Success rate of up to 100% and synthesis as low as 10 days enable versatile applications of this immense pool of chemical compounds such as:
The database is developed constantly in series of careful tests. Millions of reactions were carried out during the last years to accumulate the synthetic statistics with considerable predictive power. Over 40 liquid-phase reactions and more than 50 synthetic protocols were optimized to yield individual compounds with standard 90%+ purity. The technology of high throughput synthesis based on RDB was introduced in the year 2000 and since that time over 1.5 million compounds have been synthesized in multi-milligram quantities. Nowadays about 240,000 new compounds produced via RDB procedures are added to our stock Screening Collection annually. Each year over 10,000 new building blocks are made available by our chemists for synthesis of compound libraries. The technology of parallel synthesis can be also applied to custom building blocks taking advantage of substantial number of reagents already available at Enamine.