Advertisement Kuecept's ProRelease™ Microparticle Delivery System Patent Application Granted - Pharmaceutical Business review
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Kuecept’s ProRelease™ Microparticle Delivery System Patent Application Granted

The ProRelease™ delivery system is a multi-particulate solid intermediate that can be easily incorporated into conventional oral solid dosage formulations, including capsules and tablets and can be tailored to achieve specific release profiles, including modified, delayed and targeted release. The technology is particularly applicable to improve the bioavailability of poorly soluble basic compounds, as well as facilitate the delivery of compounds that are pH labile, induce gastric irritancy or require site specific targeting to achieve maximum absorption. In addition, the technology offers additional benefits compared to current modified release dosage forms, including:

  • Reduced variability of drug gastric emptying time
  • No significant fed / fasted variability, lowering dependency on the nutrition state
  • Lower intra- and inter-individual variability of dissolution of the drug substance
  • Lower intra- and inter-individual variability of absorption of the drug substance into the
    systemic circulation
  • Increased residence times of the drug within the lower intestine. Options for targeted delivery
    for localised dissolution to improve absorption and reduce dose

The ProRelease™ delivery system is already being evaluated by a number of major pharmaceutical
companies worldwide for products entering clinical development, as well as compounds requiring
reformulation or life cycle management. If you would like more information on the technology or
have any technical issues you would like to discuss, please contact Dr Mark Saunders, development
director.