CTL Laboratories - Contract Immune Monitoring and Research

Cellular Technology Limited (CTL) specializes in GLP-compliant ELISPOT testing for pre-clinical and clinical trials involving the measurement/characterization of T cell responses in various species.

For example, ELISPOT is ideal for Th1/Th2 analysis, measurement of per cell cytokine production and direct ex-vivo cytotoxicity assays. Testing for simultaneous secretion of one or more products e.g. cytokines, T cell functional avidity studies, or epitope mapping, are just a few areas where ELISPOT assays are used.

High throughput capability in a GLP compliant environment

CTL's GLP Laboratory has high throughput capability, allowing us to significantly accelerate the development process for drugs and vaccines entering the clinical testing phase, as well as subsequent immune-monitoring. CTL provides laboratory services for processing whole blood and cryo-preservation of lymphocytes for later functional assay testing. CTL has been providing contract research services to government laboratories, major pharmaceutical companies, and academic institutions for over a decade in a regulated or non-regulated environment. In its relatively short history, CTL has been chosen repeatedly to serve as a reference laboratory for ELISPOT, including the Immune Tolerance Network, and most recently, the Sabin Vaccine Institute's Cancer Vaccine Consortium. CTL has been awarded multiple IDIQ contracts by the U.S. National Institute of Health (NIH) for development and validation of human and animal models of infectious diseases and bio-defense applications. Furthermore, CTL has optimized, qualified, and validated test methods for its clients in various test systems: human, mouse, monkey, and pig, among others. This has provided CTL a wealth of expertise encompassing a wide range of assay types (ELISPOT, ELISA, multiplex bead arrays; CBA and Flow Cytometry) in a regulated and non-regulated environment.

Quality assurance

CTL not only has a CLIA certified and GLP-compliant laboratory operation, but also specializes in developing and manufacturing image analysis-based high throughput 21 CFR Part 11 compliant instrumentation and software. For ELISPOT assays, we have developed the ImmunoSpot© Analyzer line. Our scientists built and patented the first ELISPOT reader at Case Western Reserve University, and CTL has since become the leading manufacturer of ELISPOT instrumentation and analysis software. In recent years, CTL further customized and optimized our instruments, introducing the BioSpot© Analyzer for various applications and platforms, e.g., viral plaque assays and bacterial colony counting. This has allowed us to enter into entirely new markets while advancing the research in these fields. With our expertise in both ELISPOT testing and instrumentation, CTL is uniquely qualified to be at the forefront of cytokine-based immune monitoring and standardization strategies.

Contact details

Cellular Technology Limited
20521 Chagrin Boulevard
Shaker Heights, OH 44122-5350 USA
+1 216-791-5084 Phone - +1 216-791-8814 Fax
info@immunospot.com - www.immunospot.com