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Sulfoximines for Drug Design

Incorporation of sulfoximine group into bioactive compounds often improves their ADME/Tox profile and enhances potency. Moreover, the moiety of sulfoximine is chemically and metabolically stable. NH-sulfoximines can serve as the both hydrogen bond donors and acceptors at the same time. Production and commercialization of the building blocks that already contain sulfoximine group allow significant accelerating discovery of drug candidates. Herein we have designed and synthesized a library of sulfoximines for drug design.

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