Sulfonyl chlorides (-SO₂Cl) are widely used in medicinal chemistry and agrochemistry as precursors to pharmacologically important sulfonamides. Many sulfonyl chlorides with heteroaromatic substituents, however, are unstable due to SO₂ extrusion. More stable sulfonyl fluorides (-SO₂F) in many cases are the only option to synthesize the desired sulfonamides. They are less reactive so that they might even have a free aliphatic amino group in their structure. Besides unique monofunctional sulfonyl fluorides, Enamine offers a wide array of scaffolds and linker compounds.

The fluoride rescues the lead:

• Stable to moisture
• Improved selectivity
• Orthogonal reactivity to many other functional groups
• Scaffolds

-SO₂F probes in chemical biology

The SO₂F group covalently binds to the residues of serine, threonine, tyrosine, lysine, cysteine, and histidine in proteins. Sulfonyl fluorides are widely used as chemical probes and covalent protein inhibitors.

Our offer:

>200 Sulfonyl fluorides (-SO₂F) in gram amounts in stock. Custom synthesis of further analogues and compound libraries.