In 2016, chemists showed that replacing a benzene ring in the neurotropic compound Leteprinim with a skeleton of cubane beneficially affected activity and water solubility of the parent compound. Since then the cubane-containing building blocks are gaining high popularity in drug discovery projects, as mimics for the benzene ring.

Synthesis

We synthesized cubane-1,4-diester 1 in 100 g scale following the literature protocol, and used it for the synthesis of diverse cubane-containing building blocks.

Our offer:

Currently, we have synthesized 6 cubane-containing building blocks, that are available in our EnamineStore on a gram scale