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Analogues of CF3-Pyridine for Drug Design

More than 100 FDA-approved drugs contain pyridine ring and another 100 have been in clinical trials. Examples containing CF3-pyridine moiety include the antiviral drug Tipranavir and drug candidates Taranabant, Velneperit, SB-705498. Besides, CF3-pyridine containing compounds have been playing a fundamental role in agrochemistry. The introduction of fluorine-containing group alters important pharmacokinetic properties of molecular scaffolds. At Enamine were designed and synthesized a library of CF3-substituted pyridine analogues for drug design and agrochemistry. The design and list of more than 100 unique CF3-pyridine analogues you can find at MedChem Highlights section of Enamine’s website.