More than 70 FDA-approved drugs contain the piperidine moiety. Piperidine-based analogues may advantageously alter important pharmacokinetic properties such as lipophilicity and metabolic stability when grafted onto molecular scaffolds. Synthetic strategies for setting new spirocyclic, fused and bridged sp3-rich scaffolds are in high demand in the medicinal chemistry community. Herein, we have designed and synthesized a library of piperidine analogues for drug design.
>100 unique piperidine analogues on a 5-50 g scale from stock.
Design and full list you can find at MedChem Highlights section of Enamine’s website or in the white paper attachment.