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Helvoet Pharma

Primary and Secondary Packaging Components

More info about Helvoet Pharma

Cartridge Components

Helvoet Pharma

Helvoet Pharma has a proven track record in the development of sophisticated closure solutions for cartridge delivery systems, ensuring ultimate protection for your valuable product.

Elastomeric cartridge components must be capable of performing a variety of functions. The plunger, for one, is made of specialised bromobutyl-based formulations with all the necessary physical, chemical and mechanical properties to ensure safe and easy administration and a very low E&L profile. The components’ hardness also ensures the maximum PBSI (Plunger Barrel Seal Integrity), even after several years of storage.   Cartridge components

At the other end of the cartridge, the combiseal must be capable of maintaining the integrity of the seal, even after multiple piercings, while ensuring the lowest possible E&L profile. If necessary, bi-layer seals can also be incorporated, thus combining two compounds, each with its unique set of properties.

Optimised extractables and leachables profile

The long-term contact between the drug and the rubber components places high demands on the compatibility profile of the seal. Which is why Helvoet Pharma employs the most advanced formulations based on halobutyl elastomers to meet the multiple challenges of cartridge closure components.

Superior usability and resilience

The compatibility requirements of cartridge closure components, however, are often in conflict with the other functional properties such as self-sealing , particularly for products like insulin where multiple piercings are the norm. Helvoet Pharma’s solution is a combi-seal featuring a dual compound elastomeric liner inside the aluminium cap. The inner layer is constructed from low E&L profile halobutyl elastomers for maximum compatibility, while the outer layer is made from polyisoprene providing an extremely robust liner for multiple piercings.

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