This allows for superior resolution between fragments, monomers, and aggregates. TSKgel UltraSW Aggregate covers the range of higher molecular weights and provides a very good separation of antibody dimers and higher aggregates. It is based on smaller silica particles with slightly larger pore size than the SuperSW mAb columns.
TSKgel SuperSW and UltraSW particles are based on highly porous, ultra-pure silica particles, the surface of which has been shielded from interacting with proteins by applying a proprietary surface chemistry. This ensures highest recoveries and accurate quantitation. TSKgel SW columns stand out from other silica-based high performance size exclusion columns by virtue of their large pore volumes. The validated manufacturing and packing process ensures a reliable batch-to-batch reproducibility.