Non-invasive on-line detection of pH and oxygen

On-line detection of oxygen and pH at a small scale can be used as a basis for latter cultivation in large-scale bioreactors to detect optimal growth conditions.

Contamination-free on-line monitoring of culture parameters is not only important for scaling up production in process development, but it could also be valuable for other applications such as tissue engineering, stem cell research, and toxicological tests.

Harry Abts1 and Sarina Arain2, 1Celonic GmbH, Karl-Heinz-Beckurts-Straße 13, Jülich, Germany, 2PreSens GmbH, Josef-Engert-Str. 11, 93053 Regensburg, Germany