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TES Pharma and EPFL establish R&D collaboration

TES Pharma and École Polytechnique Fédérale de Lausanne (EPFL) has formed new research and development collaboration on novel small molecule modulators of the kynurenine pathway as therapies for metabolic disorders and age-related diseases.

The collaboration brings together TES Pharma, a research-based biotech company led by Professor Roberto Pellicciari (Scientific Co-Founder of Intercept Pharmaceuticals, Inc) with state of the art research facilities in Corciano (Perugia) and long running experience in modulators of the kynurenine pathway and metabolic disorder drug discovery, with the Laboratory of Integrative and Systems Physiology (LISP) at EPFL, led by Professor Johan Auwerx (Professor and Nestlé Chair in Energy Metabolism) pioneers in the role of NAD+ biosynthesis in metabolic disorders and ageing.

Professor Roberto Pellicciari President and CSO of TES Pharma said, "Combining our respective expertise provides an exciting platform for novel drug discovery with a world leader in metabolic disorders and ageing. "Taking forward small molecule therapies for these multi-faceted diseases requires detailed knowledge of the underlying basic biology, so we’re very excited about the opportunity work with LISP and Professor Auwerx to develop new disease-modifying therapies for these disorders."

"The collaboration with TES Pharma capitalises on our interests in signalling and transcriptional events that underlie the pathogenesis of ageing and many metabolic diseases, and will pave the way for novel therapeutic agents for these diseases," said Professor Johan Auwerx. "Our long-standing and fruitful collaboration with Professor Pellicciari will be an assurance for success!"