Alnylam, Cubist Reports Preliminary Data From Phase II Study Of ALN-RSV01

Published: 08-Jun-2009

Rsv01, an RNAi therapeutic in development, for treatment of respiratory syncytial virus infection.

Alnylam and Cubist have reported preliminary data from their Phase II study of Aln-Rsv01, an RNAi therapeutic in development for the treatment of respiratory syncytial virus (RSV) infection.

The Phase II study was a randomized, double-blind study of inhaled Aln-Rsv01 or placebo in adult lung transplant patients infected with RSV.

In the study, 24 lung transplant patients with confirmed RSV infection were randomized to receive inhaled Aln-Rsv01 or placebo once daily for three consecutive days.

Overall, the study achieved its primary objective of demonstrating safety and tolerability of Aln-Rsv01 over 30 days post treatment.

Akshay Vaishnaw, Senior Vice President of Clinical Research at Alnylam, said: “We are pleased with the preliminary results of our Phase II study as we have documented for the first time the safety and tolerability of inhaled Aln-Rsv01 in naturally infected patients, which we consider an important step forward in the advancement of our overall Aln-Rsv program toward both pediatric and adult patient populations.”

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