Small Molecule Microarrays

This new high-throughput method has been designed for straightforward and rapid screening of natural and chemical compound libraries (1). The method is based on non-covalent immobilisation of compounds that allows analysing different type of molecules on the same surface in a single binding assay.

There is no chemical reactions to immobilise molecules and the support is tolerant to solvents (DMSO, DMF). Screening can be performed against both catalytic site and protein-protein interaction surface of target proteins. Several proteins can be simultaneously probed in parallel binding assays. Different approaches have been successfully tested to distinguish between binding to a druggable site and to other protein regions (promiscuous interactions). Low soluble compounds can be screened as well.

(1) Sakanyan V. Eur. Biopharm. Review  November, 74-78 (2008).

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