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Ion Channel, GPCR, Transporter and Enzyme Assay Kits

We offer a broad range of bioanalytical assay kits that enable researchers to study molecular function and pathway analysis, particularly efforts focused on calcium mobilisation, ion channel activity and function, GPCR biology, and transporter function. In addition, researchers can leverage our assay kits to measure contamination levels in food and water, detect host cell DNA introduced during the biopharmaceutical manufacturing process, and assess kinase, phosphatase, and phosphodiesterase enzyme activity.

GPCR assays, G-protein coupled receptor assays

Abnormal function, expression, and regulation of G-protein-coupled receptors (GPCRs) have been implicated in many diseases. Molecular Devices provides a number of assay kits to support GPCR life science and drug discovery research, including assays that monitor the accumulation of a second messenger, such as cAMP/cGMP, calcium, or beta-arrestin, in response to GPCR activation, instead of traditional and limited ligand-binding assays.

Ion channel assays

FLIPR Membrane Potential Assay Kits from Molecular Devices deliver higher throughput than previous automated FLIPR System protocols while showing good correlation with manual patch clamp data.

IMAP enzyme assays

Molecular Devices’ proprietary IMAP® technology provides researchers with a non-radioactive, generic assay applicable to a wide variety of protein kinases, phosphatases, and phosphodiesterases. IMAP technology is a homogeneous "mix and read" platform amenable to high throughput screening.

Transporter assays

Molecular Devices offers two transporter assay kits for researchers studying transport targets. With the Neurotransmitter Transporter Uptake Assay Kit, researchers can screen for live-cell kinetic uptake for three key neurotransmitters: serotonin, norepinephrine and dopamine. The QBT™ Fatty Acid Uptake Assay Kit lets users monitor fatty acid transporter protein activity with real-time uptake kinetics and is ideally suited for high throughput screening applications. Both assay kits eliminate the use of radioactive compounds resulting in easier reagent handling, reduced disposal costs, and elimination of safety risks associated with radiolabel assays.

Contaminant detection assays

Molecular Devices offers two contaminant detection assay kits under its Threshold brand. The Threshold Immunoligand Assay (ILA) measures a broad range of analytes such as proteins and microorganisms for biopharmaceutical development and production. The Threshold Total DNA Assay Kit quantitatively measures picograms of single-stranded DNA with broad sequence specificity. Established for over ten years, the Threshold Total DNA Assay Kit is used by pharmaceutical and biotechnology companies worldwide and is recognised by the Food and Drug Administration (FDA) for DNA contaminate testing.

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