We manufacture peptides up to 50 amino acids in length and in quantities that can range from a gram to multi-10kg quantities. Our robust, economical manufacturing processes help optimise the cost of development.
A full range of synthetic technologies are available. The final choice depends on the sequence length, the scale, and the specific project requirements.
LPPS is the technology of choice for manufacturing short peptides or structures that are inappropriate for a resin matrix. This approach ultimately provides a cost-effective process for large-scale manufacture of multi-10kg to multi-100kg lots.
SPPS is the technology of choice for manufacturing most peptides in up to multi-10kg quantities, especially those with longer, more complex sequences. We offer both Fmoc- and tBoc-based solid-phase manufacturing.
This technology, which involves coupling shorter, SPPS generated sequences together in solution, is particularly suitable for some longer peptide structures, offering higher yields than “straight-through” SPPS.
Modern preparative high-pressure liquid chromatography (HPLC) technology has greatly facilitated the bulk manufacture of high purity peptides, suitable for pharmaceutical applications. Thanks to the available technology, the latest equipment and high level expertise, the PolyPeptide Group is capable of achieving the necessary purity of products at almost any scale, from a few grams or less to a 100kg or more.
Purification is usually performed by liquid-phase chromatography, using:
Final isolation of peptides is typically achieved by lyophilisation, using:
Alternative isolation procedures such as precipitation and spray drying, which can be scaled to process significantly larger single lots than lyophilisation permits, are being explored for appropriate APIs.