Bioactivity Determination

How can you be sure of the precise mechanism of the fertility enhancer or inhibitor under study? What is the exact reproductive function the compound is targeting? EggCentris simulates the entire female reproduction system in vitro and helps you understanding its biological activity.

EggCentris simulates the reproductive cycle in vitro. This provides a powerful tool to elucidate the mode of action of compounds directly at the target organ. In vitro tests exclude any disturbance caused by the effects of other physiological systems. This enables more goal-oriented research, accelerates your development time, and increases the reliability of your test results.

Broadly applicable, multiparametric tests

EggCentris has developed a number of in vitro bioassays that allow the in vitro exposure of all possible target systems in the female reproductive system:

• Follicle bioassay (FBA): multiparametric test for simultaneous evaluation of folliculogenesis, steroidogenesis, and oogenesis as it mimics in vitro the physiological processes of the ovary
• In vitro maturation assay (IVM): multi parametric assay to evaluate the meiotic process of the oocyte
• In vitro fertilisation assay (IVF): verifies how the compound can disturb the process of conception
• Mouse embryo assay (MEA): analyses pre-implantation embryo development

EggCentris also performs short term in vivo and ex vivo studies:

• Super)ovulation induction study: will assess ovarian responsivity to gonadotropins
• Embryo transfer study: test to assess embryo quality
• Implantation study: test to assess uterine receptivity
• Pharmacokinetic study (PK): blood collection (plasma/serum by cardiac puncture)

We also develop new testing models on your request, fully adapted to your specific needs and the compounds under study.