An Tanghe, Manager of reMYND’s CRO said:
"The support of IWT will enforce an explorative trajectory resulting in a substantiated choice when it comes to the diversification of our portfolio of services. Specific aim of the dedicated project is the selection of synaptic markers and behavioral assays for a broadening of our current offering, hereby taking into account the state of the art in the Alzheimer domain, the interest from our (prospective) clients, and the specific characteristics of our transgenic Alzheimer models."
Adherent to the specific project application, a follow-up project has already been set out, comprising the validation of correlations/co-variances between the onset of the newly established synaptic markers and behavioral/cognitive performance. By extension, also other neuropathological read-outs at the level of brain, blood and CSF will be included.
This meta-analysis will allow the mapping of the pathological changes seen in reMYND’s AD animal models at different ages vis-à-vis the described disease progression in patients at different stages, in order to increase the translational predictability of the respective AD animal models. Furthermore, these data will enable the assessment of suitable biomarkers predictive of therapeutic improvement of cognitive performance in early stages of the treatment.
As such, reMYND’s CRO intends to meet the strong need of pharmaceutical and biotech companies active in the Alzheimer domain, to have a more predictive pre-clinical in-vivo assay that would allow them to better design their as yet largely unsuccessful clinical trials, and by extension to increase the chances of successful clinical development of potent and safe pharmaceuticals for treating this devastating disease.