Hybrigenics Services will perform yeast two-hybrid (Y2H) screens on selected proteins strongly suspected to be involved in late-onset Alzheimer disease (AD), and blow up extensive protein interaction maps around them. This expanded network information will be crossed with data from human genome-wide genetic association studies to validate the relevance of susceptibility genes for AD. Hybrigenics Services will receive €0.6m over four years.
After the Genethon’s project on limb-girdle muscular dystrophies (see Hybrigenics’ press release of 14 March 2013), AgedBrainSYSBIO represents the second scientific endeavour of similar large scale to which Hybrigenics will contribute with its functional proteomics expertise.
"The concept of matching proteomics and genomics information to pin-point the most relevant gene-protein couples is gaining momentum in the life science community. It is one of the key features of the hot new field called systems biology, in which Hybrigenics Services is naturally settling," said Remi Delansorne, Hybrigenics Services’ President.