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RCSI and Almac Discovery Enter Research Collaboration

The Royal College of Surgeons (RCSI) in Ireland and Almac Discovery have announced a major research collaboration that aims to gain a new understanding of how to target tumour cells that are resistant to cancer therapies and cause cancer to spread to other parts of the body.

The project will explore the potential of a drug, based on initial research by RCSI’s Professor Tracy Robson and developed by Almac Discovery, which is currently undergoing a Phase I dose escalation trial for patients with solid tumours. It is expected that the trial will be expanded in a biomarker selected patient population within ovarian cancer. However, the drug (ALM201) has the potential to treat a range of other cancers.

Ovarian cancer ranks among the top ten diagnosed and top five deadliest cancers in most countries. Unfortunately, approximately 80% of ovarian cancer diagnoses have advanced disease, and it is critical that clinicians are provided with as many treatment options as possible that can target this disease, both as a monotherapy and in combination with existing therapies.

Led by head of molecular and cellular therapeutics professor Robson, the research team at RCSI will investigate a certain type of cell that is present in all tumours known as cancer stem cells. These cells are resistant to both radiotherapy and chemotherapy, and can facilitate the spread of cancer around the body.

The research will focus on how a novel protein called FKBPL, which occurs naturally in the body and has a unique ability to target cancer stem cells, can transform them into more normal tumour cells. These cells can then be more easily killed by chemotherapy and radiotherapy, reducing the risk of cancer reoccurrence in the patient.

Professor Robson said: “Cancer stem cells are a major barrier to successful radiotherapy and chemotherapy and can result in failure of these treatments. Our initial data demonstrates that ALM201 can transform these cells so they are no longer resistant to these therapies. This is a promising development and will complement the anti-angiogenic activity already demonstrated for this drug.

“This means that ALM201can block the formation of tumour blood vessels that would otherwise allow cancer to continue to grow. The funding provided by Almac will enable us to carry out further research in order to fully understand the mechanism behind its anti-cancer stem cell activity.

“This research is a key step on the journey to making this treatment available to patients for whom all other forms of therapy have failed.”

President and managing director at Almac Discovery Stephen Barr added: “ALM201 continues to surprise us as we uncover the complexities of its effects. The interaction of ALM201 with cancer stem cells, if proven with this research, opens up potential further treatment options for cancer patients that can be explored in the clinic.”

RCSI is ranked in the top 250 institutions worldwide in the Times Higher Education World University Rankings (2016-2017). It is an international not-for-profit health sciences institution, with its headquarters in Dublin, focused on education and research to drive improvements in human health worldwide.

Almac Discovery is a research-driven oncology company dedicated to the discovery and development of novel and innovative approaches to the treatment of cancer. Almac Discovery focuses on the discovery to preclinical stage seeking to partner programmes at an early time point with the pharmaceutical industry. Exceptionally the company will undertake clinical development to an early stage before partnering. Almac Discovery is part of the Almac Group.