By Don Walter (Thomson Reuters)

Thomson Reuters has been indexing chemistry in patents for Derwent World Patents Index since before the development of commercial structure search engines. This paper will discuss the challenges of indexing specific and Markush entities from patents; how the development of new technologies has impacted chemical patent searching over time and, in particular, how recent developments are re-invigorating the Markush space, opening up the potential of "end-user" Markush searching and the development of new tools for understanding and using the "patent space" especially in drug development.

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