Crystallisation of complexes (such as protein / protein, protein / nucleic acid, protein / ligand, nucleic acids / nucleic acid and nucleic acid / ligand) are frequently tedious and either time or sample consuming, even on well-characterised biological systems.

The success rate of complex crystallisation can be significantly improved if a proper preliminary characterisation of the complex using biophysical methods is performed.

It well established that dynamic light scattering (DLS) is key to evaluating sample crystallisability.