Taylor dispersion analysis (TDA) is an orthogonal technique for sizing and stability studies of biomolecules in solution. Studies have shown that hydrodynamic radius (Rh) measurements from TDA on monodisperse systems such as monoclonal antibodies (mAbs) are comparable to data obtained using the well-established and complementary technique of dynamic light scattering (DLS).

Protein stability is one of the primary concerns during biopharmaceutical development, as it negatively impacts upon immunogenicity and potency of the biotherapeutic.

Screening of candidate molecules for developability under a variety of formulation conditions is, therefore, a critical aspect in the early stages of the development pipeline.