FieldPrints™ and field-based overlays have shown themselves to be a robust method for locationg new leads for medicinal chemistry programs. Unlike docking protocols, no x-ray protein information is required and only 2D structures are needed for two or more ligands known to act at the same site. Thus, the technique is applicable to many classes of target for which no acceptable lead-finding solution currently exists because the technique is based on the surface properties of molecules.