While being able to measure particles of below 1nm size, dynamic light scattering (DLS) is preferentially sensitive to larger particles due to the sixth-power relationship between particle radius and scattering intensity.
This means that sample preparation typically needs to be scrupulous, especially for low scattering samples such proteins and biological molecules. The contribution to contaminants such as dust and aggregates can be mitigated by filtering, however, this may not always be practical or possible depending on the volume and fragility of the sample.
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