The Culex automated in vivo sampling system is designed to collect pharmacokinetic and pharmacodynamic (PK/PD) data during the course of drug metabolism experiments.
The Culex systems can collect blood, bile, urine, feces, and dialysates with greatly reduced trauma and stress from awake, freely moving animals. In addition, an electronic report on both the dosing and the blood sampling experiments is generated automatically, the company said.
According to the company, Culex’s versatility makes possible a wide variety of PK/PD studies in small rodents, greatly reducing the number of animals used whilst increasing the number of samples per animal, and allowing dosing and sampling of animals, day or night.
With Culex, researchers gain the opportunity to undertake full PK/PD studies in the same animal. In addition, researchers can monitor a wide range of physiological parameters such as blood pressure, body temperature, respiratory rates, ECG, urinary frequency and animal movement alongside more traditional pharmacokinetic parameters, the company said.