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Latest White Papers
Understanding Taylor Dispersion Analysis
| By Malvern Instruments
Taylor Dispersion Analysis (TDA) is a microcapillary flow-based technique whereby a nanoliter-scale sample pulse is injected into the laminar flow of run buffer, which then spreads out axially due to the combined actions of convection and radial diffusion. Detection of the equilibrium concentration profile (or Taylorgram) of the dispersed sample pulse allows the molecular diffusion coefficient and hence hydrodynamic radius of solute molecules to be calculated.
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Understanding the Conformational Stability of Protein Therapeutics using Raman Spectroscopy
| By Malvern Instruments
The combination of Dynamic Light Scattering (DLS) with Raman Spectroscopy provides the ability to extract a wealth of chemical, structural, and physical information about biotherapeutic proteins under formulation conditions.
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Understanding the Effect of Molecular Weight and Structure on the Performance Characteristics of Cellulose Derivatives using OMNISEC
| By Malvern Instruments
A key family of molecules of interest to the pharmaceutical industry is those derived from cellulose such as hydroxyethyl cellulose and others. These macromolecules are typically used as viscosity modifiers for various products such as eye drops and moisturizing creams, and as excipients in many other applications.
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Understanding Yield Stress Measurements
| By Malvern Instruments
The yield stress characteristic is a property associated with numerous types of complex fluids - whereby the material does not flow unless the applied stress exceeds a certain value. To read more, click here.
White Papers
Understanding Yield Stress Measurements
| By Malvern Instruments
Many complex fluids, such as network forming polymers, surfactant mesophases, emulsions etc do not flow until the applied stress exceeds a certain critical value, known as the yield stress. Materials exhibiting this behavior are said to be exhibiting yield flow behavior. The yield stress is therefore defined as the stress that must be applied to the sample before it starts to flow. Below the yield stress the sample will deform elastically (like stretching a spring), above the yield stress the sample will flow like a liquid.
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Use of the new MicroCal PEAQ-ITC System for Measurement and Characterization of a Broad Range of Protein-LMW Compound Interactions
| By Malvern Instruments
This white paper highlights the beneficial features of the new MicroCal PEAQ-ITC instrument and software for the analysis of binding interactions through direct and competitive titrations.
White Papers
User vs. Software-Dependent Variability of ELISPOT Counts Obtained from ten Different Laboratories
| By CTL Laboratories
In ELISPOT assays, cytokine spots produced by antigen-specific T cells show a broad spectrum of sizes and densities over variable background. Therefore, even experienced investigators are likely to come up with different spot counts when subjectively judging the minimal spot size/density to be counted and the maximal spot size for the cut off between singlecell-derived spots vs. those created by cell clusters. This study aims to find out whether statistics-based automated gating can harmonize spot counts obtained in different laboratories.
Contract Research & Services > Clinical Trials > White Papers
Using a Phenom™ Personal Electron Microscope Spurs Innovation in Paper Development at Boise, Inc.
| By Phenom World
Boise Inc., headquartered in Boise, Idaho, manufactures packaging products and papers including corrugated containers, containerboard, label and release and flexible packaging papers, imaging papers for the office and home, printing and converting papers, newsprint, and market pulp.
White Papers
Using Differential Scanning Calorimetry to Accelerate Liquid Formulation Development for Protein Biopharmaceuticals
| By Malvern Instruments
Monoclonal antibody development projects exist for a wide variety clinical indications. Recombinant proteins of commercial interest, including monoclonal antibodies, need additional properties beyond their biological activity to enable their development into successful biopharmaceuticals.
White Papers
Using Differential Scanning Calorimetry to Inform and Accelerate Process Development for Protein Therapeutics
| By Malvern Instruments
The production and purification of immunoglobulins of the gamma isotype, particularly human IgG1, for diagnostic or therapeutic applications is now fairly routine. In the past decade IgE-based therapeutics have also gained momentum (1-3). IgE is important for host defense against parasites and for protective inflammation. Yet, IgE-mediated signaling through its receptors is also a focal point of inflammatory allergic disease (4). The constant region of IgE, is a homodimer containing duplicate pairs of three unique Ig-fold domains (Cε2, Cε3, and Cε4), and is responsible for binding its two receptors, FcεRI and CD23, also known as FcεRII.
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Using Laser Diffraction Particle Size Data to Optimise the Performance of Sprays
| By Malvern Instruments
Many industries share the need to closely control the characteristics of sprays, albeit for very different reasons, and one of the most critical parameters is the particle size of the droplets within the spray plume.
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Using the Best Stability Chamber
| By BINDER Pharma
When choosing the size of the stability chamber or room, certain considerations must be taken into effect. Today permanent location is a concern, with the flexibility of today's market with the vast amount of merger and acquisitions that take place. Being flexible is very important as well as the cost to relocate. Many times the cost to relocate is close to the cost originally constructed.
Production & Manufacturing > Process & Production > White Papers
Using the Zetasizer Nano to Optimize Formulation Stability
| By Malvern Instruments
Formulation development is a critical activity for many industries, from pharmaceuticals, to paints and coatings. Indeed, it is estimated that in the UK alone, sales of formulated products amount to some £180 billion per year1. This means that getting formulation ‘right’ is an important goal, with considerable value attached to it. Stability is a crucial attribute for many products with a direct impact on performance, shelf-life, kerb appeal and ultimately, worth. A systematic approach to understanding and developing stability can therefore be extremely helpful in improving the likelihood of success in long-term stability trials and accelerating formulation. The Zetasizer range from Malvern is the world’s most widely used system for nanoparticle, colloid and protein size and zeta potential measurements. In this whitepaper, we examine how these capabilities can be exploited to develop stable dispersions.
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Utilising Big Data to Produce Faster and Cheaper Clinical Research
| By Medical Research Network
The Medical Research Network White Paper – By Dr Graham Wylie September 2013.
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