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Latest White Papers
Tablet-In-Cup Drug Delivery Device - Drug Release Modification by Tablet Geometry
| By Medelpharm
A poster on Tablet-in-Cup Drug Delivery Device (so-called TIC’s) made by University of Basel (Master thesis Leonie HATTLER) was recently presented at the Pharma Science Day in Bern and received the ‘Best Poster Award in Pharmaceutical Technology’. Line No. 3 materials and methods are of special interest for Medelpharm. The tablets were made with a Medelpharm STYL’One Classic including a tab-in-tab device.
Production & Manufacturing > Process & Production > White Papers
Taking the Strain
| By Eppendorf
Today, the rapidly expanding demand for vaccine products for viral diseases such as rabies has necessitated the development of more sophisticated production techniques based around cell culture systems. This article reviews vaccine production strategies, with a focus on rabies, looking specifically at the use of the Vero cell line - used worldwide and approved by the US Food and Drug Administration - as well as media technology and the bioreactor options available.
White Papers
Taming China's Clinical Trial 'Dragon'
| By World Courier
With a population in excess of 1.3 billion and low technical costs, China is a highly attractive venue for clinical trials. In this article, current regulations and permit requirements are examined and a transportation case study is presented. Local solutions and important considerations for choosing appropriate "in country" service providers are also discussed.
Contract Research & Services > Contract Research > White Papers
TAPI 2009 Product List
| By TAPI
This free white paper provides a comprehensive list of all TAPI's products, including all new products and upcoming ones.
White Papers
Target Immobilization and NMR Screening of Fragments in Early Drug Discovery
| By ZoBio
Using localized NMR spectroscopy on immobilized targets provides us with a method to simultaneously assess binding of small molecules to two different samples. This Target Immobilized NMR Screening (TINS) has a number of advantages, not least is the requirement for minimal quantities of non-isotopically labeled protein and the applicability to insoluble or unstable targets. The technique is sensitive to binding with KD values in the range of 100 nM to 20 mM, while careful selection of the reference protein reduces the number of false positive hits. This combination ensures a maximal number of valid hits from which to select starting points for hit elaboration projects. Hits can be prioritized using biological assays when appropriate, as well as an array of biophysical techniques. So far a variety of soluble proteins, including kinases, GTPases, viral targets and proteases, as well as a membrane protein, have been successfully screened against our fragment library. Here we illustrate our experiences with a number of examples which emphasize the usefulness of the method in selecting and prioritizing fragment hits for elaboration towards leads.
White Papers
Tech Talk: CHANGING GMP BEHAVIORS with NSF
| By NSF Health Sciences Pharma Biotech PBR
Most people are content sticking with what they know and their tried and tested habits. It’s easy. To get people to think and act differently (a painful process for most), you have to provide them with the motivation.
White Papers
Technology for API Solubility
| By Laboratoria Smeets
Water solubility is a big challenge for some medicines. In many cases water solubility is related to bioavailability and hence the effectiveness of the API.
White Papers
Temperature management – from local to global
| By TSS
If temperature data can't be processed, visualised and compared on a global basis, the true performance will never be revealed. TSS's temperature management system helps pharmaceutical companies understand global performance and how it could be improved.
Contract Research & Services > Clinical Trials > White Papers
Temperature Monitoring Solution - CCIS
| By TSS
CCIS provides centralised control over global operations performance and is tailored to suit each user level. No matter your corporate role, CCIS helps you tackle the challenges you face, both today and tomorrow.
Contract Research & Services > Clinical Trials > White Papers
Ten Criteria for Selecting Your Optimal Weighing Solution
| By Sartorius Group
Do you really know what criteria are key to selecting a scale that ideally suits your needs? Nowadays, scales are offered in such a wide range of shapes and sizes that choosing one can be a daunting task. To find out more, please download this free white paper.
Automation > Laboratory Instrumentation > White Papers
Ten Reasons Polymer Characterization Scientists Should Upgrade From Single to Multi-Detector GPC
| By Malvern Instruments
This white paper lists the top ten reasons to consider an advanced multi-detector GPC system.
White Papers
Ten Reasons That the Zetasizer Nano is Chosen for Scientific Success
| By Malvern Instruments
New components and measurement techniques continue to be introduced for the Zetasizer Nano. New to the system are a Surface Zeta Potential accessory and a new diffusion barrier method for improved zeta potential measurements of protein samples. Why is the Malvern Zetasizer Nano so popular and found in a broad range of applied and fundamental scientific projects across all industries and fields? Because, it is simply the most dynamic and broad ranged instrument on the market for solving technical issues in today's research environment and it continues to evolve with new capabilities. Here are ten reasons why you should choose the Zetasizer Nano:
White Papers
Ten Ways to…..Control Rheology by Changing Particle Properties (Size, Zeta Potential and Shape)
| By Malvern Instruments
Many common materials can be considered to be dispersions in which one substance (often particulate) is dispersed in another phase. These material types include adhesives, agrochemicals, cement, ceramics, colloids, cosmetics and personal care formulations, food and drink, mining and mineral slurries, paints, inks and surface coatings, pharmaceuticals and polymer systems.
White Papers
Ten Ways to…Optimise Rheology to Increase Dispersion/Colloidal/Emulsion Stability
| By Malvern Instruments
The following ten points highlight general methods of designing and interpreting rheological tests to optimise sample stability.
White Papers
The Benefits of Real-Time Analysis for Process Development
| By Malvern Instruments
While much effort is expended in optimizing commercially operating plant, getting the process 'right first time' can be far more efficient. Real-time analysis of process parameters provides substantial support during development, streamlining and accelerating the evolution of successful process designs. Taking on-line particle size analysis as an example, this paper considers the rationale for investing in real-time measurement for pilot scale work. Case studies illustrate the various ways in which on-line systems promote efficient process development, easing the transition into profitable manufacture.
White Papers
The Challenges of Pilot Testing Translated PRO Measures with Children
| By RWS Group
Pilot testing measures in linguistic validation exercises with children poses a unique set of challenges. The methods for meeting these challenges and alternatives to pilot testing with children are the topics of this paper.
White Papers
The Informed Design and Validation of Quality of Life Questionnaires and Rating Scales Using Rasch Analysis
| By Exploristics
This free white paper describes how some of the additional outputs from Rasch analysis can provide information beyond that of a simple analysis of the QoL data during the creation and validation of a new instrument or to understand and quantify responses following a clinical study.
White Papers
The Mark–Houwink plot – Differentiation of Branching and Composition
| By Malvern Instruments
In this application note, we will show how to separate the effects of a structural difference induced by a compositional change to a polymer (e.g. substitution) and the structural change induced by polymer chain branching.
White Papers
The new MicroCal PEAQ-DSC Automated System
| By Malvern Instruments
Eight reasons to upgrade from the MicroCal VP-Capillary DSC system. Use of Differential Scanning Calorimetry (DSC) in biopharmaceutical development. Differential scanning calorimetry (DSC) is an established biophysical tool for protein stability characterization during biopharmaceutical drug development. DSC data are used to advance the most stable and 'developable' proteins into the pipeline, and optimize the process and formulation conditions to maintain protein stability during manufacturing and storage.
White Papers
The Process of Informed Consent
| By CenterWatch
In this ACRP guidance document, the Association describes how to best structure the informed consent process in accordance with best practices.
Contract Research & Services > Clinical Trials > White Papers
The Pulse on Recruitment -- Exploring the Use of Social Media and Online Tactics in Patient Recruitment
| By CenterWatch
Industry experts Cara Danchak and Bonnie A. Brescia offer insight into the challenges and potential benefits of social media and online patient recruitment.
Contract Research & Services > Clinical Trials > White Papers
The Pulse on Recruitment--Recruiting patients on TV and radio
| By CenterWatch
Learn effective tips and strategies to draw the most response out of your television and radio recruitment campaigns.
Contract Research & Services > Clinical Trials > White Papers
The Pulse on Study Conduct -- Best Practices and Critical Strategies to Ensure Site Success
| By CenterWatch
Industry expert Elizabeth Blair Weeks-Rowe offers solutions to achieve study conduct success from ensuring clean data to preparing for a co-monitoring visit.
Contract Research & Services > Clinical Trials > White Papers
The Role of Biostatistics in the Prevention, Detection and Treatment of Fraud in Clinical Trials
| By CluePoints
Recent cases of fraud in clinical trials have attracted considerable media attention, but relatively little reaction from the biostatistical community. In this paper we argue that biostatisticians should be involved in preventing fraud (as well as unintentional errors), detecting it, and quantifying its impact on the outcome of clinical trials.
Contract Research & Services > Clinical Trials > White Papers
The Urgent Need for Qualified Transportation Providers in Global Clinical Research
| By World Courier
In light of sobering statistics from the MHRA, WHO and others about the quality of temperature-controlled drugs and medicinal products arriving at global research sites, regulatory agencies and pharmaceutical companies alike are demanding that every party involved in the pharmaceutical supply chain conform to GxP guidelines. This article outlines the main precepts of GxP as it applies to the pharmaceutical transport industry and offers insight on securing the global CTM supply chain.
Contract Research & Services > Contract Research > White Papers
The Use of Ambulatory Blood Pressure Monitoring in Drug Development; Copyright, January 2015
| By ERT
This white paper delves into the basics of blood pressure, along with the well-documented limitations of standard and digital office blood pressure measurements. It reviews ABPM device functionality, common drug classes where blood pressure monitoring comes into play and compares the advantages and disadvantages of different monitoring options in clinical studies.
White Papers
The Use of Continuous ECG Recordings (Holters) in Drug Development; Copyright, December 2014
| By ERT
Continuous 12 lead ECG recorders, often referred to as Holter devices, offer specific advantages to be considered over the standard 12 lead ECGs often collected during clinical trials for cardiac safety. This white paper explores the history of Holters, how sponsors, sites, and patients use these devices, and the benefits of continuous ECG recordings.
White Papers
The Use of EDXRF for Pharmaceutical Material Elemental Analysis
| By PANalytical
This study demostrates that the X-ray Fluorescence (XRF) technique is capable of performing elemental analysis of all of these pharmaceutical (liquid, powder and solid) materials with high sensitivity, precision and accuracy.
Automation > Laboratory Instrumentation > White Papers
The use of GMP-Compliant Aluminium Pallets in your Industry
| By Muskita Aluminium Industries Ltd
Learn about aluminium. It will transform your logistics. It is: Anti static (unlike plastic), Antimagnetic, Food safe, No fire hazard (reduced insurance bills), Less weight than wood, -50o to +200o work environments, Watertight & resilient, Customized sizes and dimensions available, Permanent antimicrobial coatings available upon request, 100% recyclable, High residual value, Extremely durable, Easy to clean and sterilize, No fumigations needed, No UV damages.
White Papers
The use of ITC for Obtaining Enzyme Kinetic Constants
| By Malvern Instruments
Enzymes are proteins that function as biological catalysts and they play a crucial role in nearly all processes that take place in living organisms. Therefore studies of these molecules and the reactions they catalyze have been a core activity for biochemists for at least the past fifty years.
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