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Technology for API Solubility
| By Laboratoria Smeets
Water solubility is a big challenge for some medicines. In many cases water solubility is related to bioavailability and hence the effectiveness of the API.
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Medelpharm Corporate Flyer
| By Medelpharm
After over 70 years of deep-rooted passion for high precision engineering, Medelpharm now put the design and development of R&D tablet presses and tableting technologies in the focus of its operations.
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NTA: Exosomes and Microvesicles - General
| By Malvern Instruments
The study of exosomes and other cell-derived microvesicles is an area of rapidly growing importance and the subject of intense interest and research. The previous lack of suitable methods for their detection, analysis, enumeration and phenotyping is proving to be a significant limitation in these studies. This chapter shows the degree to which the technique of NTA is helping to address these problems.
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High Cell Density Fermentation of Escherichia coli Using the New Brunswick™ BioFlo® 115
| By Eppendorf
This application note presents a successful example of a high density fermentation of Escherichia coli (E. coli) using the New Brunswick BioFlo 115 benchtop, autoclavable fermentor from Eppendorf. The highest optical density (OD600) achieved in this study was 140 at 11 hours (h) without optimized fermentation medium and conditions.
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Addressing the Needs of Drug Discovery with the MicroCal PEAQ-ITC Instruments
| By Malvern Instruments
This white paper highlights the advantages of the new ITC instruments—MicroCal PEAQ-ITC and MicroCal PEAQ-ITC Automated systems and MicroCal PEAQ-ITC Analysis Software. The software allows analysis of binding interactions complicated by the presence of inactive protein material, incorrect protein concentration, and/or inaccurate concentration or heterogeneity of compound solutions.
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Use of the new MicroCal PEAQ-ITC System for Measurement and Characterization of a Broad Range of Protein-LMW Compound Interactions
| By Malvern Instruments
This white paper highlights the beneficial features of the new MicroCal PEAQ-ITC instrument and software for the analysis of binding interactions through direct and competitive titrations.
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Microcal ITC Systems
| By Malvern Instruments
Understanding biomolecular interactions.
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Important Factors when Buying a Differential Scanning Calorimeter (DSC)
| By Malvern Instruments
The physical components and features of a Differential Scanning Calorimeter (DSC) instrument and the technical specifications are clearly important to consider when purchasing a new system. However, written specifications can be confusing, misleading and may actually have very little bearing on the actual performance of the instrument. Specifications, on paper, do not necessarily translate into advantages or disadvantages when it comes to making measurements on your samples.
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Understanding the Effect of Molecular Weight and Structure on the Performance Characteristics of Cellulose Derivatives using OMNISEC
| By Malvern Instruments
A key family of molecules of interest to the pharmaceutical industry is those derived from cellulose such as hydroxyethyl cellulose and others. These macromolecules are typically used as viscosity modifiers for various products such as eye drops and moisturizing creams, and as excipients in many other applications.
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Forensic Analysis of an Artificial Sweetener Commonly Employed in Hoax Powder Attacks Using Morphologically Directed Raman Spectroscopy
| By Malvern Instruments
In the wake of the September 11th terrorist attacks, there was an influx of white powder events throughout the United States. A white powder event is when an unknown white powder is received in the post. More often than not, the attacks do not contain any toxic materials and are carried out for the sole purpose of causing terror and damaging infrastructure. Since these attacks, the FBI and US Postal Service have responded to thousands of white powder events.
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