Log in or Register for enhanced features | Forgotten Password?
White Papers | Suppliers | Events | Report Store | Companies | Dining Club | Medical Devices | Videos
Pharmaceutical Business Review
Return to: PBR Home | Suppliers

Malvern Instruments – Pharmaceutical Equipment Supplier Case Studies

Malvern Instruments – Pharmaceutical Equipment Supplier

Differential scanning calorimetry as a diagnostic tool for cancer patients Blood serum is a source of cancer biomarkers. Tumor development is accompanied by metabolic malfunction that may result in altered serum composition: proteins that are up/downregulated and low molecular weight metabolites undergoing changes in concentration.
Read case study
Polymer Nanoparticle Characterization Using Dynamic Light Scattering Polymer nanoparticles are being used as drug delivery systems. This applications discusses the influence of temperature on the size of polymer nanoparticles using dynamic light scattering.
Read case study
The impact of electrode particle size and shape on battery slurry viscosity Using Morphologi G3 to monitor and control the electrode particle characteristics and viscosity of battery slurries.
Read case study
GPC/SEC analysis of polymer branching Using triple detection GPC/SEC to understand branching in polymers
Read case study
Concentration limits for zeta potential measurements in the Zetasizer Nano Explains the concentration limits for successful zeta potential measurements to be made. A case study is used to illustrate the limits of concentration and describes what happens to the quality of data if the sample concentration is inappropriate.
Read case study
The power of multi-detector SEC in the analysis of antibodies How OMNISEC can measure antibody absolute MW independent of size and structural changes.
Read case study
Particle size analysis of cement using the technique of laser diffraction The critical strength and curing properties of cement are dependent on the particle size distribution of the cement components. This note describes how laser diffraction can be used as a routine method for cement particle size analysis.
Read case study
Malvern Instruments: GPC/SEC Analysis of Polymer Degradation Understanding the effects of processing a polymer on its molecular weight, molecular weight distribution, and solution viscosity are important to manufacturers. Knowing whether a recycled or reground polymer will still fall within specifications can save time and money. Knowing what the polymer characteristics are at end use can help avoid failures and improve specifications.
Read case study
Malvern Instruments: How to use GPC/SEC for Compositional Analysis Over the last century, as synthetic polymers became more prevalent, a desire arose to fine-tune the physical properties of these materials to produce the optimal end-product for a given application. One method researchers explored was to mix two or more types of monomers so that a single chain of the resulting polymer would be a combination and potentially possess a unique set of physical properties. Copolymers, the term used to describe these polymers consisting of two or more different constituent units, can exhibit a variety of monomer patterns and structures (e.g. random, alternating, block, comb). While the monomer arrangement and overall shape of the copolymers can affect their physical properties, so can the relative concentration of each monomer present.
Read case study
Malvern Instruments explores how Switching Mobile Phases can Improve your OMNISEC Results Analysis of ester- and acid-capped PLGA samples in mobile phases of DCM and THF.
Read case study
Malvern Instruments: Multi-detector GPC/SEC analysis of polysaccharides using OMNISEC How moving to multi-detector GPC can give greater insight than conventional measurements.
Read case study
Processing non-Newtonian products: Determining the pressure drop for a power law fluid along a straight circular pipe In the chemical and process industries, it is often required to pump fluids over long distances from storage to various processing units and/or from one plant site to another. It is thus often necessary to calculate the pressure requirements for pumping, the selection of optimum pipe diameter as well as measurement and control of flow rate. Many of the formulae required to estimate such parameters are available in the literature and require some knowledge of these processing parameters as well as fluid properties.
Read case study
MicroCal PEAQ-DSC Brochure by Malvern Instruments Biomolecular stability analysis for the regulated environment
Read case study
How investing in Malvern Instruments helped KBI Biopharma find a clear commercial advantage Written by Dr. Amber Fradkin of KBI Biopharma, who manages the Particle Characterization Core Facility at KBI Biopharma in Boulder, Colorado.
Read case study
Using Squeeze Flow to Extend Rheological Measurements for Concentrated Suspensions Making shear rheological measurements on samples with a high solids fraction can present difficulties on a rotational rheometer, since the sample can be prone to fracture even at low-medium shear rates.
Read case study
Using Laser Diffraction to Characterize Casein Micelles and Fat Globules in Milk To improve its shelf-life, milk undergoes a homogenization process. This process produces fat globules of a uniform, small size. During the homogenization process the size range of the fat globules is reduced from 0.1-15 μm in unprocessed milk to 1-2 μm in homogenized milk [1]. These smaller globules cannot form large enough clusters for creaming to occur, increasing the shelf-life of the milk.
Read case study
Introducing Morphologically-Directed Raman Spectroscopy A powerful tool for the detection of counterfeit drugs
Read case study
Time to Harness the True Power of Rheology Upgrading from a viscometer to a modern rotational rheometer brings access to a range of test methods that can be applied to accelerate and enhance the formulation of personal care products
Read case study
On the Same Wavelength: Calcium Carbonate Particle Size and Laser Technology Malvern Instruments embarks on particle size analysis of carbon carbonates by utilising laser diffraction, a technique adopted for the use of sizing particles in materials of vastly different parameters.
Read case study
Nothing's Set in Stone: Component Characterization of Cements using Morphologi G3-ID Via technology that features static, automated imaging combined with Raman spectroscopy, Malvern Instruments examines the characteristics and behaviours of individual cement components.
Read case study
A Thirst for Knowledge: Malvern Instruments Monitors Microfiltration Processes for Water Treatment Malvern dives into quantifying nanoparticle concentration and size to optimize filtration processes
Read case study
The Dynamism of DSC in Membrane Behaviour To reveal the basics of liposome sample preparation and DSC studies, Malvern Instruments uses this fundamental technique to characterize thermotropic phase transitions in lipid bilayer membranes
Read case study
Characterization of Protein-Protein Interactions using Triple Detection Size Exclusion Chromatography (SEC-TD) The ability of proteins to form ordered, structured complexes is central to their biological function. Such complexes, which can be homo-oligomers or heterooligomers, can control different attributes such as activity, stability and localization. Understanding how these complexes form, and the controlling mechanism behind them, is fundamental to our knowledge of protein signaling pathways and the physiological responses they control.
Read case study
Comparing the Rheology and Particle Size of Smoothies Made with Different Blenders Smoothies have been around for the best part of a century although it was not until the development, commercialization and evolution of the blender between 1920 and 1950 that home-made smoothies (in the modern sense) became possible. Their popularity was further accelerated by the health food movement of the 1960’s and more recently the commercialization of dedicated smoothie makers, combined with a trend towards natural and nutritious foods.
Read case study
Evaluating Product Spreading Characteristics on a Rotational Rheometer Using the Power Law Model The rheological properties of a product can influence how it is visually and texturally perceived by a consumer and how it is likely to behave during product use. For example very shear thinning materials will be highly responsive to changes in applied stress while Newtonian materials will show much lesser dependence. Such a response is important when considering the ease of spreading or ‘spread-ability’.
Read case study
Analysis of Demicellization Data from Isothermal Titration Calorimetry Many industrial and biochemical applications depend on the usage of detergents and other surfactants. These compounds are indispensable, in particular, for the extraction, purification, and handling of membrane proteins. Owing to their amphiphilic nature, detergents can provide a membrane-mimetic environment required by integral membrane proteins to retain their native structures and functions in aqueous solution. Oftentimes, different detergents have to be screened to identify one that is suitable for the solubilization, stabilization, reconstitution, and biophysical, biochemical, or structural scrutiny of the protein of interest.
Read case study
Optimizing Fluid Rheology for Enhanced Oil Recovery Applications In this case study we present elements of the work carried out by Rafael Hincapie as part of his PhD project at TU Clausthal to better understand how viscoelastic properties of EOR polymers influence oil recovery performance. We show how non-linear viscoelastic measurements made on a rotational rheometer can be used to help explain the behavior of viscoelastic polymers in the porous media and how this behaviour is influenced by environmental conditions.
Read case study
Characterization of IgG Monomers & Their Aggregates A comparison between column calibration & multi-detection SEC.
Read case study
Optimization of PLA/PLGA Molecular Weight and Structure to Suit Final Application Requirements The biodegradable and biocompatible polymers, PLA and PLGA are used in many different applications including, amongst others, food packaging, farming materials, biomedical devices such as absorbable surgical thread and implants such as stents or drug release systems. 3D-printing is another application which benefits from the low melt processing temperature of PLA. Usually, PLA and PLGA are based on monomers from renewable sources, so are considered "green" polymers. By selecting different molecular weights, different ratios of lactic:glycolic acid and different molecular structures, some properties such as degradation or drug release rates can be tailored to meet application needs. GPC/SEC analysis is an ideal tool for monitoring samples during material synthesis, production of parts and in degradation studies.
Read case study
Differentiation of Polymer Branching and Composition Using the Mark–Houwink Plot In this application note, we will show, using polystyrene, how to separate the effects of a structural difference induced by a compositional change (bromination) and the structural change induced by polymer chain branching using the Mark- Houwink plot.
Read case study